Artificial cannabinoids have also been utilized recreationally because they are inexpensive and are usually not discovered with the conventional marijuana drug checks. Not like nabilone, the synthetic cannabinoids found being used for recreational use didn't have any documented therapeutic consequences.[38]
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PB-22 and 5F-PB-22 had been the very first artificial cannabinoids to include a quinoline substructure and an ester linkage. These compounds are thought to have been synthesized with the intention of creating a synthetic cannabinoid prodrug, which could increase absorption and confound detection. Ester bonds are easily biodegradable by way of spontaneous or endogenous, nonspecific esterase hydrolysis, which has been frequently used in medicinal chemistry for making ester prodrugs.
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